I am about to start on xeloda which i ordered from canada drug pharmacy for a 10th of the cost,, since i do not have drug coverage.
Information about Xeloda.
The pharmacokinetics of XELODA and its metabolites have been evaluated in about 200 cancer patients over a dosage range of 500 to 3500 mg/m 2dayOver this rangethe pharmacokinetics of XELODA and its metabolite5DFCR were dose proportional and did not change over timeThe increases in the AUCs of 5DFUR and 5-FUhoweverwere greater than proportional to the increase in dose and the AUC of 5-FU was 34higher on day 14 than on day 1The interpatient variability in the Cmax and AUC of 5-FU was greater than 85
Plasma protein binding of capecitabine and its metabolites is less than 60and is not concentrationdependentCapecitabine was primarily bound to human albuminapproximately 35XELODA has a low potential for pharmacokinetic interactions related to plasma protein binding.
NoteBreast Cancer News is strictly a news and information website about the diseaseIt does not provide medical advicediagnosis or treatmentThis content is not intended to be a substitute for professional medical advicediagnosisor treatmentAlways seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical conditionNever disregard professional medical advice or delay in seeking it because of something you have read on this website.
The following data are shown for the combination study with XELODA and docetaxel in patients with metastatic breast cancer in Table 7 and Table 8In the XELODA and docetaxel combination arm the treatment was XELODA administered orally 1250 mg/m 2 twice daily as intermittent therapy2 weeks of treatment followed by 1 week without treatmentfor at least 6 weeks and docetaxel administered as a 1hour intravenous infusion at a dose of 75 mg/m 2 on the first day of each 3-week cycle for at least 6 weeksIn the monotherapy arm docetaxel was administered as a 1-hour intravenous infusion at a dose of 100 mg/m 2 on the first day of each 3-week cycle for at least 6 weeksThe mean duration of treatment was 129 days in the combination arm and 98 days in the monotherapy armA total of 66 patients26in the combination arm and 4919in the monotherapy arm withdrew from the study because of adverse reactionsThe percentage of patients requiring dose reductions due to adverse reactions was 65in the combination arm and 36in the monotherapy armThe percentage of patients requiring treatment interruptions due to adverse reactions in the combination arm was 79Treatment interruptions were part of the dose modification scheme for the combination therapy arm but not for the docetaxel monotherapy-treated patients.
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having spoken to my oncologist who advised me that i had a 95 clearance from chemo he wpuld like me to go on xeloda for 6 months to prevent a reoccurance.